COVID-19 | Scandinavian research contributions

Scandinavian researchers are hard at work helping to address the COVID19 pandemic. This post has a list of key contributions from our shores

The SSAI board wants to highlight some of the excellent work done by SSAI colleagues during this pandemic on understanding and providing treatments for SARS-CoV-19 infections.

This list below of published peer reviewed contributions was collated by Prof Michael Haney, editor-in-chief of Acta.

Last update: 10th September 2020.

Any new articles you want us to hightlight, get in touch.

Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).

Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A. Crit Care Med. 2020 Jun;48(6):e440-e469. doi: 10.1097/CCM.0000000000004363.  PMID: 32224769 Free PMC article.

Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan.

Petersen MW, Meyhoff TS, Helleberg M, Kjær MN, Granholm A, Hjortsø CJS, Jensen TS, Møller MH, Hjortrup PB, Wetterslev M, Vesterlund GK, Russell L, Jørgensen VL, Tjelle K, Benfield T, Ulrik CS, Andreasen AS, Mohr T, Bestle MH, Poulsen LM, Hitz MF, Hildebrandt T, Knudsen LS, Møller A, Sølling CG, Brøchner AC, Rasmussen BS, Nielsen H, Christensen S, Strøm T, Cronhjort M, Wahlin RR, Jakob S, Cioccari L, Venkatesh B, Hammond N, Jha V, Myatra SN, Gluud C, Lange T, Perner A. Acta Anaesthesiol Scand. 2020 Jul 21:10.1111/aas.13673. doi: 10.1111/aas.13673. Online ahead of print.  PMID: 32779728 Free PMC article.

Characteristics and outcomes of patients with COVID-19 admitted to ICU in a tertiary hospital in Stockholm, Sweden.

Larsson E, Brattström O, Agvald-Öhman C, Grip J, Campoccia Jalde F, Strålin K, Nauclér P, Oldner A, Konrad D, Persson BP, Eriksson LI, Mårtensson J; Karolinska Intensive Care COVID-19 Study Group. Acta Anaesthesiol Scand. 2020 Sep 6. doi: 10.1111/aas.13694. Online ahead of print.  (Open Access) PMID: 32892337

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C, Filipovic I, Ponzetta A, Aleman S, Cornillet M, Hertwig L, Strunz B, Lentini A, Reinius B, Brownlie D, Cuapio A, Ask EH, Hull RM, Haroun-Izquierdo A, Schaffer M, Klingström J, Folkesson E, Buggert M, Sandberg JK, Eriksson LI, Rooyackers O, Ljunggren HG, Malmberg KJ, Michaëlsson J, Marquardt N, Hammer Q, Strålin K, Björkström NK; Karolinska COVID-19 Study Group. Sci Immunol. 2020 Aug 21;5(50):eabd6832. doi: 10.1126/sciimmunol.abd6832. PMID: 32826343

Managing ICU surge during the COVID-19 crisis: rapid guidelines.

Aziz S, Arabi YM, Alhazzani W, Evans L, Citerio G, Fischkoff K, Salluh J, Meyfroidt G, Alshamsi F, Oczkowski S, Azoulay E, Price A, Burry L, Dzierba A, Benintende A, Morgan J, Grasselli G, Rhodes A, Møller MH, Chu L, Schwedhelm S, Lowe JJ, Bin D, Christian MD. Intensive Care Med. 2020 Jul;46(7):1303-1325. doi: 10.1007/s00134-020-06092-5. Epub 2020 Jun 8. PMID: 32514598 Free PMC article. Review.

High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission.

Agarwal A, Basmaji J, Muttalib F, Granton D, Chaudhuri D, Chetan D, Hu M, Fernando SM, Honarmand K, Bakaa L, Brar S, Rochwerg B, Adhikari NK, Lamontagne F, Murthy S, Hui DSC, Gomersall C, Mubareka S, Diaz JV, Burns KEA, Couban R, Ibrahim Q, Guyatt GH, Vandvik PO. Can J Anaesth. 2020 Sep;67(9):1217-1248. doi: 10.1007/s12630-020-01740-2. Epub 2020 Jun 15. PMID: 32542464 Free PMC article.

Humoral Immune Response to SARS-CoV-2 in Iceland.

Gudbjartsson DF, Norddahl GL, Melsted P, Gunnarsdottir K, Holm H, Eythorsson E, Arnthorsson AO, Helgason D, Bjarnadottir K, Ingvarsson RF, Thorsteinsdottir B, Kristjansdottir S, Birgisdottir K, Kristinsdottir AM, Sigurdsson MI, Arnadottir GA, Ivarsdottir EV, Andresdottir M, Jonsson F, Agustsdottir AB, Berglund J, Eiriksdottir B, Fridriksdottir R, Gardarsdottir EE, Gottfredsson M, Gretarsdottir OS, Gudmundsdottir S, Gudmundsson KR, Gunnarsdottir TR, Gylfason A, Helgason A, Jensson BO, Jonasdottir A, Jonsson H, Kristjansson T, Kristinsson KG, Magnusdottir DN, Magnusson OT, Olafsdottir LB, Rognvaldsson S, le Roux L, Sigmundsdottir G, Sigurdsson A, Sveinbjornsson G, Sveinsdottir KE, Sveinsdottir M, Thorarensen EA, Thorbjornsson B, Thordardottir M, Saemundsdottir J, Kristjansson SH, Josefsdottir KS, Masson G, Georgsson G, Kristjansson M, Moller A, Palsson R, Gudnason T, Thorsteinsdottir U, Jonsdottir I, Sulem P, Stefansson K. N Engl J Med. 2020 Sep 1. doi: 10.1056/NEJMoa2026116. Online ahead of print. PMID: 32871063

Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid.

Virhammar J, Kumlien E, Fällmar D, Frithiof R, Jackmann S, Sköld MK, Kadir M, Frick J, Lindeberg J, Olivero-Reinius H, Ryttlefors M, Cunningham JL, Wikström J, Grabowska A, Bondeson K, Bergquist J, Zetterberg H, Rostami E. Neurology. 2020 Sep 8;95(10):445-449. doi: 10.1212/WNL.0000000000010250. Epub 2020 Jun 25. PMID: 32586897

Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study.

El-Boghdadly K, Wong DJN, Owen R, Neuman MD, Pocock S, Carlisle JB, Johnstone C, Andruszkiewicz P, Baker PA, Biccard BM, Bryson GL, Chan MTV, Cheng MH, Chin KJ, Coburn M, Jonsson Fagerlund M, Myatra SN, Myles PS, O’Sullivan E, Pasin L, Shamim F, van Klei WA, Ahmad I. Anaesthesia. 2020 Jun 9:10.1111/anae.15170. doi: 10.1111/anae.15170. Online ahead of print. PMID: 32516833 Free PMC article.

COVID-19 patients with respiratory failure: what can we learn from aviation medicine?

Ottestad W, Søvik S. Br J Anaesth. 2020 Sep;125(3):e280-e281. doi: 10.1016/j.bja.2020.04.012. Epub 2020 Apr 18. PMID: 32362340 Free PMC article. No abstract available.

COVID-19 Assessment with Bedside Lung Ultrasound in a Population of Intensive Care Patients Treated with Mechanical Ventilation and ECMO.

Møller-Sørensen H, Gjedsted J, Lind Jørgensen V, Lindskov Hansen K. Diagnostics (Basel). 2020 Jul 2;10(7):447. doi: 10.3390/diagnostics10070447. PMID: 32630707 Free PMC article.

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC, Murthy S, Diaz JV, Slutsky AS, Villar J, Angus DC, Annane D, Azevedo LCP, Berwanger O, Cavalcanti AB, Dequin PF, Du B, Emberson J, Fisher D, Giraudeau B, Gordon AC, Granholm A, Green C, Haynes R, Heming N, Higgins JPT, Horby P, Jüni P, Landray MJ, Le Gouge A, Leclerc M, Lim WS, Machado FR, McArthur C, Meziani F, Møller MH, Perner A, Petersen MW, Savovic J, Tomazini B, Veiga VC, Webb S, Marshall JC. JAMA. 2020 Sep 2. doi: 10.1001/jama.2020.17023.  Online ahead of print. PMID: 32876694

Decision support tool and suggestions for the development of guidelines for the helicopter transport of patients with COVID-19.

Bredmose PP, Diczbalis M, Butterfield E, Habig K, Pearce A, Osbakk SA, Voipio V, Rudolph M, Maddock A, O’Neill J. Scand J Trauma Resusc Emerg Med. 2020 May 25;28(1):43. doi: 10.1186/s13049-020-00736-7. PMID: 32450877 Free PMC article.

[COVID-19: Swiftness and solidarity].

Moller AD. Laeknabladid. 2020 Jun;106(6):289. doi: 10.17992/lbl.2020.06.583. PMID: 32491989 Icelandic. No abstract available.

Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients.

Eriksson O, Hultström M, Persson B, Lipcsey M, Ekdahl KN, Nilsson B, Frithiof R. Thromb Haemost. 2020 Sep 1. doi: 10.1055/s-0040-1715835. Online ahead of print. PMID: 32871607

Nationwide Incidence and Outcomes of Patients With Coronavirus Disease 2019 Requiring Intensive Care in Iceland.

Kristinsson B, Kristinsdottir LB, Blondal AT, Thormar KM, Kristjansson M, Karason S, Sigvaldason K, Sigurdsson MI. Crit Care Med. 2020 Aug 11:10.1097/CCM.0000000000004582.  doi: 10.1097/CCM.0000000000004582. Online ahead of print. PMID: 32796182 Free PMC article.

The good, the bad and the ugly: pandemic priority decisions and triage.

Flaatten H, Van Heerden V, Jung C, Beil M, Leaver S, Rhodes A, Guidet B, deLange DW. J Med Ethics. 2020 Jun 10:medethics-2020-106489. doi: 10.1136/medethics-2020-106489. Online ahead of print. PMID: 32522814 Free PMC article.

Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project).

Juul S, Nielsen N, Bentzer P, Veroniki AA, Thabane L, Linder A, Klingenberg S, Gluud C, Jakobsen JC. Syst Rev. 2020 May 9;9(1):108. doi: 10.1186/s13643-020-01371-0. PMID: 32386514 Free PMC article.

Strategies to handle increased demand in the COVID-19 crisis: A coronavirus EMS support track and a web-based self-triage system.

Jensen T, Holgersen MG, Jespersen MS, Blomberg SN, Folke F, Lippert F, Christensen HC. Prehosp Emerg Care. 2020 Sep 1:1-16. doi: 10.1080/10903127.2020.1817212. Online ahead of print. PMID: 32870754

European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients.

Terheggen U, Heiring C, Kjellberg M, Hegardt F, Kneyber M, Gente M, Roehr CC, Jourdain G, Tissieres P, Ramnarayan P, Breindahl M, van den Berg J. Pediatr Res. 2020 Jul 7. doi: 10.1038/s41390-020-1050-z. Online ahead of print. PMID: 32634819 Review.

Association of Nonsteroidal Anti-inflammatory Drug Use and Adverse Outcomes Among Patients Hospitalized With Influenza.

Lund LC, Reilev M, Hallas J, Kristensen KB, Thomsen RW, Christiansen CF, Sørensen HT, Johansen NB, Brun NC, Voldstedlund M, Støvring H, Thomsen MK, Christensen S, Pottegård A. JAMA Netw Open. 2020 Jul 1;3(7):e2013880. doi: 10.1001/jamanetworkopen.2020.13880. PMID: 32609352 Free PMC article.

Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort.

Reilev M, Kristensen KB, Pottegård A, Lund LC, Hallas J, Ernst MT, Christiansen CF, Sørensen HT, Johansen NB, Brun NC, Voldstedlund M, Støvring H, Thomsen MK, Christensen S, Gubbels S, Krause TG, Mølbak K, Thomsen RW. Int J Epidemiol. 2020 Sep 5:dyaa140. doi: 10.1093/ije/dyaa140. Online ahead of print. PMID: 32887982

Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials.

Sterne JAC, Diaz J, Villar J, Murthy S, Slutsky AS, Perner A, Jüni P, Angus DC, Annane D, Azevedo LCP, Du B, Dequin PF, Gordon AC, Green C, Higgins JPT, Horby P, Landray MJ, Lapadula G, Le Gouge A, Leclerc M, Savović J, Tomazini B, Venkatesh B, Webb S, Marshall JC; WHO COVID-19 Clinical Management and Characterization Working Group. Trials. 2020 Aug 24;21(1):734. doi: 10.1186/s13063-020-04641-3. PMID: 32831155 Free PMC article.

Fatal pulmonary fibrosis: a post-COVID-19 autopsy case.

Schwensen HF, Borreschmidt LK, Storgaard M, Redsted S, Christensen S, Madsen LB. J Clin Pathol. 2020 Jul 28:jclinpath-2020-206879. doi: 10.1136/jclinpath-2020-206879. Online ahead of print. PMID: 32723800

Existing Data Sources in Clinical Epidemiology: The Danish COVID-19 Cohort.

Pottegård A, Kristensen KB, Reilev M, Lund LC, Ernst MT, Hallas J, Thomsen RW, Christiansen CF, Sørensen HT, Johansen NB, Støvring H, Christensen S, Kragh Thomsen M, Husby A, Voldstedlund M, Kjær J, Brun NC. Clin Epidemiol. 2020 Aug 12;12:875-881. doi: 10.2147/CLEP.S257519. eCollection 2020. PMID: 32848476 Free PMC article.

The effect of prostacyclin (Iloprost) infusion at a dose of 1 ng/kg/min for 72 hours compared to placebo in mechanically ventilated patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Johansson PI, Bestle M, Søe-Jensen P, Kristiansen KT, Stensballe J, Clausen NE, Perner A. Trials. 2020 Aug 26;21(1):746. doi: 10.1186/s13063-020-04696-2. PMID: 32847626 Free PMC article. Clinical Trial.

The promise and pitfalls of composite endpoints in sepsis and COVID-19 clinical trials.

Brown PM, Rogne T, Solligård E. Pharm Stat. 2020 Sep 7. doi: 10.1002/pst.2070. Online ahead of print. PMID: 32893957

Acute perimyocarditis with cardiac tamponade in COVID-19 infection without respiratory disease.

Dalen H, Holte E, Guldal AU, Hegvik JA, Stensaeth KH, Braaten AT, Mjølstad OC, Rossvoll O, Wiseth R. BMJ Case Rep. 2020 Aug 19;13(8):e236218. doi: 10.1136/bcr-2020-236218. PMID: 32816835 Free PMC article.

Assessment of pulmonary surfactant in COVID-19 patients.

Schousboe P, Wiese L, Heiring C, Verder H, Poorisrisak P, Verder P, Nielsen HB. Crit Care. 2020 Sep 7;24(1):552. doi: 10.1186/s13054-020-03268-9. PMID: 32894160 Free PMC article. No abstract available.

Hyperreninemia and low total body water may contribute to acute kidney injury in COVID-19 patients in intensive care.

Hultström M, von Seth M, Frithiof R. J Hypertens. 2020 Aug;38(8):1613-1614. doi: 10.1097/HJH.0000000000002531. PMID: 32472780 Free PMC article. No abstract available.

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.

Rodriguez L, Pekkarinen PT, Lakshmikanth T, Tan Z, Consiglio CR, Pou C, Chen Y, Mugabo CH, Nguyen NA, Nowlan K, Strandin T, Levanov L, Mikes J, Wang J, Kantele A, Hepojoki J, Vapalahti O, Heinonen S, Kekäläinen E, Brodin P. Cell Rep Med. 2020 Aug 25;1(5):100078. doi: 10.1016/j.xcrm.2020.100078. Epub 2020 Aug 5. PMID: 32838342 Free PMC article.

Blood type A associates with critical COVID-19 and death in a Swedish cohort.

Hultström M, Persson B, Eriksson O, Lipcsey M, Frithiof R, Nilsson B. Crit Care. 2020 Aug 12;24(1):496. doi: 10.1186/s13054-020-03223-8. PMID: 32787887 Free PMC article. No abstract available.

Has Venoarterial ECMO Been Underutilized in COVID-19 Patients?

De Piero ME, Lo Coco V, Taccone FS, Belliato M, Broman LM, Malfertheiner MV, Lorusso R. Innovations (Phila). 2020 Jul/Aug;15(4):317-321. doi: 10.1177/1556984520939076. Epub 2020 Jul 7. PMID: 32634058 No abstract available.

How likely are COVID-19 interventions to benefit the sickest patients?

Perner A, Tirupakuzhi Vijayaraghavan BK, Venkatesh B. Intensive Care Med. 2020 Jul;46(7):1441-1444. doi: 10.1007/s00134-020-06131-1. Epub 2020 Jun 9. PMID: 32519004 Free PMC article. No abstract available.

Inhibitors of the Renin-Angiotensin-Aldosterone System and Covid-19 in critically ill elderly patients.

Jung C, Bruno RR, Wernly B, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Fernandes AM, Artigas A, Pinto BB, Schefold J, Wolff G, Kelm M, De Lange DW, Guidet B, Flaatten H, Fjølner J; COVIP study group. Eur Heart J Cardiovasc Pharmacother. 2020 Jul 9:pvaa083. doi: 10.1093/ehjcvp/pvaa083. Online ahead of print. PMID: 32645153 Free PMC article. No abstract available.

Nonoperating room anesthesia for patients with serious comorbidities.

Pöyhiä R. Curr Opin Anaesthesiol. 2020 Aug;33(4):594-600. doi: 10.1097/ACO.0000000000000890. PMID: 32628408 Review.

Adverse outcomes and mortality in users of non-steroidal anti-inflammatory drugs who tested positive for SARS-CoV-2: A Danish nationwide cohort study.

Lund LC, Kristensen KB, Reilev M, Christensen S, Thomsen RW, Christiansen CF, Støvring H, Johansen NB, Brun NC, Hallas J, Pottegård A. PLoS Med. 2020 Sep 8;17(9):e1003308. doi: 10.1371/journal.pmed.1003308. eCollection 2020 Sep. PMID: 32898149

Intracranial Pressure Dynamics and Cerebral Vasomotor Reactivity in Coronavirus Disease 2019 Patient With Acute Encephalitis.

Svedung Wettervik T, Kumlien E, Rostami E, Howells T, von Seth M, Velickaite V, Lewén A, Enblad P. Crit Care Explor. 2020 Aug 14;2(8):e0197. doi: 10.1097/CCE.0000000000000197. eCollection 2020 Aug. PMID: 32885174 Free PMC article.

The other side of novel coronavirus outbreak: Fear of performing cardiopulmonary resuscitation.

Scquizzato T, Olasveengen TM, Ristagno G, Semeraro F. Resuscitation. 2020 May;150:92-93. doi: 10.1016/j.resuscitation.2020.03.019. Epub 2020 Apr 4. PMID: 32259607 Free PMC article. No abstract available.

Renewed KIDS SAVE LIVES campaign to further increase awareness and fight sudden cardiac death in the era of COVID-19.

Semeraro F, Ristagno G, Greif R, Lockey A, Monsieurs KG, Nolan JP, Olasveengen TM, Perkins GD, Scapigliati A, Böttiger BW. Resuscitation. 2020 Aug;153:183-184. doi: 10.1016/j.resuscitation.2020.06.018. Epub 2020 Jun 20. PMID: 32574653 Free PMC article. No abstract available.

Treatment with angiotensin II in COVID-19 patients may not be beneficial.

Rysz S, Jalde FC, Oldner A, Eriksson LI, Lundberg J, Fagerlund MJ. Crit Care. 2020 Sep 4;24(1):546. doi: 10.1186/s13054-020-03233-6. PMID: 32887650 Free PMC article. No abstract available.

Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?

Lönnqvist PA, Bell M, Karlsson T, Wiklund L, Höglund AS, Larsson L. Br J Anaesth. 2020 Sep;125(3):e334-e336. doi: 10.1016/j.bja.2020.05.056. Epub 2020 Jun 10. PMID: 32600801 Free PMC article. No abstract available.

Prognostication in older ICU patients: mission impossible?

Flaatten H, Beil M, Guidet B. Br J Anaesth. 2020 Aug 14:S0007-0912(20)30646-2. doi: 10.1016/j.bja.2020.08.005. Online ahead of print. PMID: 32868042 Free PMC article. No abstract available.

Invasive mechanical ventilation in a former preterm infant with COVID-19.

Nyholm S, Edner A, Myrelid Å, Janols H, Dörenberg R, Diderholm B. Acta Paediatr. 2020 Jun 22:10.1111/apa.15437. doi: 10.1111/apa.15437. Online ahead of print. PMID: 32569422 Free PMC article. No abstract available.

Cardiac arrest in a COVID-19 patient after receiving succinylcholine for tracheal reintubation.

Sigurdsson TS, Þorvaldsson AP, Asgeirsdottir S, Sigvaldason K. Br J Anaesth. 2020 Aug;125(2):e255-e257. doi: 10.1016/j.bja.2020.04.073. Epub 2020 May 1. PMID: 32423609 Free PMC article. No abstract available.

Critical illness myopathy as a consequence of Covid-19 infection.

Tankisi H, Tankisi A, Harbo T, Markvardsen LK, Andersen H, Pedersen TH. Clin Neurophysiol. 2020 Aug;131(8):1931-1932.  doi: 10.1016/j.clinph.2020.06.003. Epub 2020 Jun 12. PMID: 32619798 No abstract available.

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